Melissa Little
Murdoch Children’s Research Institute
Australia
EMBO | EMBL Symposium
This conference will take place at EMBL Heidelberg, with the option to attend virtually.
The ability to grow human tissues from stem cells in 3D culture has the potential to revolutionise the drug discovery process and regenerative medicine. Building on a long tradition of cell and developmental biology knowledge, organoids resembling a variety of human tissues have been generated. This conference will bring together the leading researchers in this field to establish a new research community and reveal parallels between various tissue models. The aim of this meeting is to bring together researchers from different fields to enhance our understanding of how organoids can be formed and maintained, how they can be used to study disease and how we might eventually use them to regenerate and replace human organ tissue
“Organoid biology is all about interaction across multiple disciplines and methods. The
EMBO | EMBL Symposium has been a wonderful venue for hosting such cross-talks.” – Francesco Cambuli, Columbia University, USA
“This conference was a great oppotunity to bring together experts on the organoid field, creating an important network for future collaborations.” – Veronica Foletto, University of Trento, Italy
“This symposium was one of the best conferences I attended so far. Beside the location and networking possibilities I would like to emphasize the great choice of speakers and posters. The presented data and new applications were astonishing and represented the development of organoid field very nicely. Thank you very much for the organization of such a great symposium.” – Thomas Däullary, Julius-Maximilians-Universität of Würzburg, Germany
Please see EMBL’s COVID-19 safety recommendations if attending the on-site event.
Murdoch Children’s Research Institute
Australia
University of Cambridge and California Institute of Technology
UK and USA
Remote speaker
Kyoto University
Japan
University of Basel
Switzerland
Max Planck Institute of Psychiatry
Germany
F. Hoffmann-La Roche Ltd, Switzerland
Switzerland
University of Toronto
Canada
Max Planck Institute of Molecular Cell Biology and Genetics
Germany
Newcastle University and Wellcome Sanger Institute
UK
University of Copenhagen
Denmark
Institute of Molecular Biotechnology (IMBA)
Austria
University of Cambridge
UK
Institute of Molecular Biotechnology
Austria
Leiden University
The Netherlands
Helmholtz Centre for Infection Research
Germany
Princess Máxima Center
The Netherlands
University of Michigan
USA
Cincinnati Children’s Hospital Medical Center
USA
Max Planck Institute for Molecular Biomedicine
Germany
Max Planck Institute of Molecular Cell Biology and Genetics
Germany
Boston Children’s Hospital and Harvard Medical School
USA
MRC Laboratory of Molecular Biology
UK
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Time (Europe/Berlin) | Speaker |
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14:00 – 16:00 | Registration and light refreshments |
14:30 – 15:30 | Pre-conference workshops with Amsbio, Carl ZEISS, Evident, STEMCELL, TakaraBio More information will be shared closer to the conference |
16:00 – 16:15 | Opening remarks by Esther Schnapp |
16:15 – 18:50 | Session 1: Concepts from development and evolution Session Chair: Madeleine Lancester – MRC Laboratory of Molecular Biology, Cambridge, UK |
16:15 – 16:40 | Charting human development with organoid single-cell technologies Gray Camp – University of Basel, Switzerland Not available on demand |
16:40 – 16:55 | The emergence of “actin stars” for epithelium coordination and tissue patterning Amlan Barai – Institut de Biologie du Développement de Marseille (IBDM) – CNRS & Aix-Marseille University, France Not available on demand |
16:55 – 17:10 | Morphogen stepwise temporal gradient-driven neural induction shapes brain organoid development into a single expanded neuroepithelium with enhanced cortical identity Anna Pagliaro – Prinses Maxima Centrum, The Netherlands Not available on demand |
17:10 – 17:40 | Coffee Break and Meet the speakers |
17:40 – 18:05 | Human iPSC Intestine Mimetics co-differentiated with Mesenchymal, Endothelial and Enteric Nervous Tissue Jason Spence – University of Michigan, USA Not available on demand |
18:05 – 18:20 | Modulation of human placental development by uterine Natural Killer cells: new insights using trophoblast organoids Elisa Magistrati – Friedrich Miescher Institute for Biomedical Research, Switzerland Not available on demand |
18:20 – 18:35 | Multimodal signal integration for tissue-scale decision making Cornelia Schwayer – Friedrich Miescher Institute for Biomedical Research, Switzerland Not available on demand |
18:35 – 18:50 | Cell type tracking in intestinal organoids reveals ‘commit-then-sort’ differentiation model Sander Tans – AMOLF institute, The Netherlands |
18:50 – 19:35 | Keynote Lecture: Extending what we know about kidney organoids to deliver on disease modelling and tissue engineering Melissa Little – Murdoch Children’s Research Institute, Australia |
19:35 – 21:05 | Dinner in Canteen |
21:05 – 23:00 | After dinner drinks |
Time (Europe/Berlin) | Speaker |
---|---|
09:00 – 12:05 | Session 1: Concepts from development and evolution (cont) Session Chair: Meritxell Huch – Max Planck Institute of Molecular Cell Biology and Genetics, Germany |
09:00 – 09:25 | Decoding the developing human immune system Muzlifah Haniffa – Newcastle University and Wellcome Sanger Institute, UK |
09:25 – 09:40 | Human Pluripotent Stem Cells-Derived Inner Ear Organoids Recapitulate Otic Development In Vitro Marta Roccio – University Hospital Zurich, Switzerland Not available on demand |
09:40 – 09:55 | Fueling Cellular Transformation: Insulin’s Dynamic Role in Generating Airway and Alveolar Lung Organoids from Endodermal NKX2.1 Cells Mirian Romitti – Université libre de Bruxelles (ULB), Belgium |
09:55 – 10:25 | Coffee Break and Meet the speakers |
10:25 – 10:50 | Organoids to probe infections Josef Penninger – Helmholtz Centre for Infection Research, Germany |
10:50 – 11:05 | Recapitulation of human early embryonic development in artificial micro-environments from notochord to gastrula Zhe Wang – Kyoto University, Japan |
11:05 – 11:20 | Spatial and temporal regulation of cell-cell fusion in human placenta Veronica Farmer – Duke University, USA |
11:20 – 12:05 | Keynote Lecture: To be presented on-site Magdalena Zernicka-Goetz – California Institute of Technology, USA Not available on demand |
12:05 – 13:30 | Lunch |
13:30-16:25 | Session 2: Building organoid complexity Session Chair: Kim Bak Jensen – University of Copenhagen, Denmark |
13:30 – 13:55 | Self-organization in pancreas organoids: formation of complex ductal networks Anne Grapin-Botton – Max Planck Institute of Molecular Cell Biology and Genetics, Germany Not available on demand |
13:55 – 14:10 | Complex intestinal organoid models to study immune-epithelial interactions Joana F Neves – King’s College London, United Kingdom |
14:10 – 14:35 | Overcoming challenges of brain organoids to uncover what it means to be pluripotent Madeline Lancaster – MRC, Cambridge, UK |
14:35 – 15:05 | Coffee Break and Meet the speakers |
15:05 – 15:30 | Reconstituting human axial development with axioloids Cantas Alev – Kyoto University, Japan Not available on demand, remote talk |
15:30 – 15:45 | Differentiating stem cells one at a time in 3D reveals how the dynamical build-up of local microniches controls tissue organisation in gastruloids and bile duct organoids Virgile Viasnoff – National University of Singapore, Singapore |
15:45 – 16:00 | Design and control of in vitro microenvironments with simple CUBE device to achieve organoid architecture Masaya Hagiwara – RIKEN, Japan |
16:00 – 16:25 | Multi-chamber cardioids unravel human heart development and cardiac defects Sasha Mendjan – Institute of Molecular Biotechnology, Austria |
16:25 – 16:45 | Flash talks #52 Reconstructing the development of fetal insulin producing enteroendocrine cells Akkerman, Ninouk #74 Light dependent modulation of microRNA expression in human retinal organoids Celiker, Canan #91 Developing an immunocompetent in vitro 3D brain model of alzheimer’s disease to study the neuroprotective effects of estrogen Demetriou, Aphrodite #112 Supracellular contractility of fibroblasts in homeostasis, injury, and wound healing Glisovic, Neda #181 Ex utero cell derived model of the human post implantation embryo development Bondarenko, Vladyslav #183 Microfluidics driven tissue patterning of neural organoids Park, JiSoo #219 Local tissue mechanics controls homeostatic live cell extrusion in the small intestine Spoelstra, Willem Kasper #243 Communication of cellular fitness in intestinal organoids van Luyk, Merel #245 Bacterial infection of intestinal organoids von Peinen, Kristin |
16:45 – 18:45 | Poster Session 1 (odd) with beer and snacks View poster listing here |
18:45 | Free evening |
Time (Europe/Berlin) | Speaker |
---|---|
09:00 – 12:00 | Session 3: Organoids from adult stem cells Session Chair: Penney Gilbert – University of Toronto, Canada |
09:00 – 09:25 | Organoids to model human disease Hans Clevers – F. Hoffmann-La Roche Ltd, Switzerland Not available on demand |
09:25 – 09:40 | PIEZO-dependent mechano-sensing of the niche is essential for intestinal stem cell fate decision and maintenance Meryem B. Baghdadi – Institut Curie, France |
09:40 – 09:55 | Multilineage liver organoids recapitulate aspects of the liver peri-portal region and faithfully model cholestatic liver disease Aleksandra Sljukic – Max Planck Institute of Molecular Cell Biology and Genetics (MPI- CBG), Germany Not available on demand |
09:55 – 10:25 | Coffee Break and Meet the speakers |
10:25 – 10:40 | Intestinal organoid and organ-on-chip models to recapitulate celiac disease pathophysiology Sebo Withoff – University Medical Center Groningen, The Netherlands Remote speaker |
10:40 – 10:55 | Host response to Pseudomonas aeruginosa and Staphylococcus aureus in an ex vivo human airway model of cystic fibrosis Pawan Parajuli – Commonwealth Scientific and Industrial Research Organisation (CSIRO), Australia |
10:55 – 11:20 | Regulation of stem cell dynamics through niche-derived signals and forces Sara Wickström – Max Planck Institute for Molecular Biomedicine, Germany Not available on demand |
11:20 – 11:45 | Esther Schnapp – Editor Talk: Transparent Publishing at EMBO Press |
11:45 – 13:30 | Lunch |
13:30 – 16:25 | Session 4: Organoids in regenerative medicine/therapy Session Chair: Anne Grapin-Botton – Max Planck Institute of Molecular Cell Biology and Genetics, Germany |
13:30 – 13:55 | Understanding interconnectedness in liver development and disease Takanori Takebe – Cincinnati Children’s Hospital Medical Center, USA, Not available on demand |
13:55 – 14:10 | Golgi organization is a determinant of stem cell function in the small intestine Sandra Scharaw – Karolinska Institutet, Sweden Not available on demand |
14:10 – 14:35 | Skin organoids for developmental modeling and therapy Karl Koehler – Boston Children’s Hospital and Harvard Medical School, USA Not available on demand |
14:35 – 15:05 | Coffee Break and Meet the editors and Meet the speakers |
15:05 – 15:30 | In silico predictions coupled with the mini-IDLE predictive assay identifies myofiber-derived biomolecules dictating muscle stem cell return to quiescence Penney Gilbert – University of Toronto, Canada |
15:30 – 15:45 | Generation of complex human induced pluripotent stem cell-derived bone marrow organoids to model hematopoietic development and disease Stephanie Frenz-Wiessner – Dr. von Hauner Children’s Hospital, Ludwig-Maximilians-University Munich, Germany Not available on demand |
15:45 – 16:00 | Cerebral organoids display dynamic clonal growth with lineage replenishment Christopher Esk – University of Innsbruck, Austria |
16:00 – 16:25 | Cardiovascular diseases and drugs: where are we with hiPSC models? Christine Mummery – Leiden University Medical Centre, The Netherlands Not available on demand |
16:25 – 16:45 | Flash talks #106 iPSC derived human organoid based model of intestinal filovirus infection Flores, Elizabeth Yvonne #164 Volumetric compression by heterogeneous scaffold embedding promotes cerebral organoid growth and maturation Ma, Shaohua #172 Generation and characterization of microglia containing human forebrain assembloids Michels, Susanne #220 Covalent tracking of DNMT1 specific activity in lung cancer spheroids Stankevicius, Vaidotas #236 Collective organization of circadian rhythms in murine intestinal organoids Tonin, Elena #238 Screening gastric cancer patient derived organoids develops the first in class anti invadopodia therapeutic antibody Tsai, Kelvin Kunchih #242 Exploring human inner ear organoids: Single cell analysis of oto-pharyngeal development and comparative profiling to human inner ear tissue across developmental stages van der Valk, Wouter #254 Differentiated tubuloids to model human distal nephron (Patho)Physiology Pou Casellas, Carla |
16:45 – 18:45 | Poster Session 2 (even) with beer and snacks View poster listing here |
18:45 – 21:00 | Conference dinner in the canteen |
21:00 – 00:00 | Party with Who2Ladies |
Time (Europe/Berlin) | Speaker |
---|---|
09:00 – 12:25 | Session 5: Organoids in disease modeling Session Chair: Karl Koehler – Boston Children’s Hospital and Harvard Medical School |
09:00 – 09:25 | Guiding Intestinal Stem Cell Fate Kim Bak Jensen – University of Copenhagen, Denmark Not available on demand |
09:25 – 09:40 | Salmonella Typhimurium and Shigella flexneri use alternative virulence strategies to colonize the human enteroid and colonoid epithelium Petra Geiser – Uppsala University, Sweden |
09:40 – 09:55 | Extracellular signaling in neurodevelopmental disorders Silvia Cappello – Ludwig Maximilian University of Munich, Germany Not available on demand |
09:55 – 10:25 | Coffee Break and Meet the speakers |
10:25 – 10:50 | Organoid cellular cancer immunity models in motion Anne Rios – The Princess Maxima Center of Pediatric Oncology |
10:50 – 11:05 | RFX6 Regulates Human Intestinal Patterning and Function J Guillermo Sanchez – Cincinnati Children’s Hospital, United States of America |
11:05 – 11:30 | Liver organoids to study regeneration and cancer across biological scales Meritxell Huch – Max Planck Institute of Molecular Cell Biology and Genetics, Germany Not available on demand |
11:30 – 11:45 | Isogenic patient-derived organoids reveal early neurodevelopmental defects in spinal muscular atrophy initiation Natalia Rodriguez-Muela – German Center for Neurodegenerative Diseases (DZNE), Germany |
11:45 – 12:10 | Genetic screening and neural network pathology in cerebral organoids Jürgen Knoblich – Institute of Molecular Biotechnology (IMBA), Austria Not available on demand |
12:10 – 12:25 | Closing Remarks and Poster Prize Announcement |
12:25 – 12:45 | Packed Lunch and departure |
12:45 | Airport shuttle to terminal 1 (30 EUR), tickets may be purchased on-site |
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Hello | Hallo |
Goodbye | Auf Wiedersehen (formal) Tschüss (informal) |
Good morning | Guten Morgen |
Good afternoon | Guten Tag |
Good evening | Guten Abend |
Good night | Gute Nacht |
I’m sorry | Es tut mir leid |
Excuse me… | Entschuldigen Sie |
How are you? | Wie gehts? |
I’m fine thanks. And you? | Mir geht es gut , danke. Und Dir/Ihnen? |
What is your name | Wie heißen Sie? (formal) Wie heißt du? (informal) |
My name is.. | Ich heiße.. |
Do you speak English | Sprechen Sie englisch? |
I don’t understand | Ich verstehe nicht |
Please speak more slowly | Können Sie bitte langsamer sprechen |
Thank you | Dankeschön |
Where is the toilet? | Wo ist die Toilette? |
Please call me a taxi | Bitte rufen Sie mir ein Taxi |
How do I get to….? | Wie komme ich zum/zur…..? |
A beer/two beers please | Ein Bier/zwei Bier bitte |
A glass of red/white wine please | Ein Glas Rot/Weisswein bitte |
The menu, please | Die Speisekarte, bitte |
Is there a local speciality? | Gibt es eine Spezialität aus dieser Gegend? |
I’m vegetarian | Ich bin Vegetarier |
It was delicious | Es war hervorragend |
The bill, please | Die Rechnung, bitte |
I have a headache | Ich habe Kopfschmerzen |
I have a sore throat | Ich habe Halsschmerzen |
My stomach hurts | Ich habe Magenschmerzen |
I’m allergic to | Ich bin allergisch gegen |
I need a doctor who speaks English | Ich brauche einen Arzt, der englisch spricht. |
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Gold Sponsors
Silver Sponsors
Bronze sponsors
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Disease Models & Mechanisms, The Company of Biologists Journal
Development, The Company of Biologists journal
EMBO Journal, an EMBO Press journal
FEBS Journal, a FEBS Press journal
FEBS Letters, a FEBS Press journal
International Union of Biochemistry and Molecular Biology
Open Biology, a Royal Society journal
Bio Essays, a Wiley Online Library
Advanced Biology, a Wiley Online Library
Sponsorship opportunities
We offer a variety of event sponsoring possibilities, with the flexibility to select a set sponsorship package or combine individual sponsorship options to suit your event budget. Discounts are available for companies sponsoring multiple events at EMBL Heidelberg. View other conferences, or contact sponsorship@embl.de for further information.
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EMBO | EMBL Symposia promote scientific communication and collaboration in the European research area. They provide scientists with a platform to discuss and exchange ideas on forward-looking topics and new developments in the life sciences.
Topics emphasise upcoming developments and the interdisciplinary nature of related fields. Jointly funded and organised by EMBO and EMBL – and complementary to their respective courses, workshops, and conference programmes – the symposia promote scientific communication and collaboration.
All symposia are held in the EMBL Advanced Training Centre (ATC) in Heidelberg, Germany, or virtually.
Want to let others know you’re attending this event? Take a look at our shareable media and feel free to use them in your social media channels or presentations.
For on-site participants only.
The following industry workshops will be hosted by the sponsors of EMBO | EMBL Symposium: Organoids: modelling organ development and disease in 3D culture prior to the start of the event.
on Wednesday 18 October 2023, 14:30 – 15:30
In order to read the abstract of each workshop, please click on the corresponding links above.
Participation in this workshop is free of charge for registered on-site conference attendees. The available place is limited (first come, first served).
All registered conference attendees will receive an email with a registration link shortly.
All pre-conference workshops will take place simultaneously, therefore, please choose the one you would be interested in the most.
Date: 18 - 21 Oct 2023
Location: EMBL Heidelberg and Virtual
Venue: EMBL Advanced Training Centre
Deadline(s):
Abstract submission: Closed
Registration (On-site): Closed
Registration (Virtual): Closed
Organisers:
Contact: Lea Hohmann